Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

Published 09 December 2021



https://www.nature.com/articles/s41569-021-00662-w
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Re: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Study investigates COVID-19 vaccines and myocarditis

12/8/21


https://www.medicalnewstoday.com/articl ... yocarditis


Link between vaccine and myocarditis


On June 23, 2021, the Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices reported a likely linkTrusted Source between mRNA COVID-19 vaccination and myocarditis, particularly in those younger than 39 years.

Because of the important health implications in the decision to vaccinate youth, it is vital to understand the effects of suspected myocarditis following COVID-19 vaccinations.

A recent study in the American Heart Association’s (AHA) flagship journal, CirculationTrusted Source, suggests that young people who experienced the myocarditis side effects from COVID-19 vaccinations recover quickly.


Study method and results


Researchers collected data from 26 centers across the U.S. and Canada. Using CDC guidelines to classify cases of myocarditis as probable or confirmed, 139 patients younger than 21 showed symptoms of myocarditis within 1 month of receiving a COVID-19 vaccination prior to July 4, 2021.

Of the 139 teens and young adults meeting the study criteria, most were white, non-Hispanic, and male, with a median age of 15.8 years.

According to symptoms, laboratory data, and imaging results, around one-third of the cases of suspected myocarditis were classified as confirmed and two-thirds as probable.

Almost 98% of all cases followed an mRNA vaccine, and 91% occurred after the second vaccine dose. Chest pain, fever, and shortness of breath were the most common symptoms the patients reported.

More than 75% of those who received a cardiac MRI showed evidence of inflammation or injury to the heart muscle. Most of these individuals were in the hospital for 2–3 days, with their illness considered mild. About 20% of the hospitalized patients were admitted to ICU, and there were no deaths.

However, the research team noted several limitations of the study. For example, there was no comparison of the incidence or risk between those who experience myocarditis because of the vaccination with those who experience cardiac symptoms following COVID-19 infection.

In addition, the authors could not rule out the possibility of a viral infection causing the myocarditis.
Further research needed

The authors note the need for future studies to evaluate the long-term outcomes for those who have had myocarditis after COVID-19 vaccinations.

Underlying genetic differences or immune responses make males especially susceptible to developing this cardiac condition. Scientists do not know these apparent risk factors.

Dr. Sanjay Prasad, a cardiologist at Mayo Clinic, London, spoke to Medical News Today regarding the need for specific follow-ups to this study:

“Important questions to address are why was this subset more susceptible, and for those developing myocarditis after one dose, how and when should they receive the second dose?”

In an interview with MNT, Dr. Ryan Serrano, assistant professor of Clinical Pediatrics at Indiana University School of Medicine and cardiologist at Riley Children’s Health, both in in Indianapolis, explained how the results chimed with his own observation:

“The patient characteristics and outcomes described here are consistent with our own experience with post-vaccine-related myocarditis, in that most cases are mild without severe involvement, such as cardiac dysfunction or arrhythmia, and patients recover quickly, especially compared with patients who get myocarditis from a viral infection like COVID-19.”

He also agrees with the need for more research relating to the future safety of people with myocarditis, especially those who are athletes:

“Athletes who experience viral myocarditis must be restricted from sports for 3–6 months,” says Dr. Serrano. However, as supported by this study, post-vaccine myocarditis seems to be milder with a faster recovery time. “Do these athletes need to rest for 3–6 months, or can they safely return to the field sooner?” he adds.

The researchers state that myocarditis, even if mild in the majority, is a cause of great concern. However, the risk must be balanced against critical illness associated with COVID-19.

“Overall, I still think the personal and public health benefits significantly outweigh the risk, and I still recommend all parents to get their children vaccinated when they are age-appropriate.”

– Dr. Serrano

The researchers conclude that COVID-19 vaccine myocarditis occurring in those younger than 21 years is resolved rapidly with only mild symptoms.

However, they recommend healthcare professionals be alert to boys and young male adults who present with chest pain after receiving a COVID-19 vaccination, especially in the first week after the second vaccination.
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Re: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Japan Panels Agree to Add Myocarditis as ADRs for Pfizer, Moderna Vaccines

December 6, 2021


https://pj.jiho.jp/article/245733

Panels of experts under the Japanese health ministry on December 3 agreed on label revisions for mRNA COVID-19 vaccines developed by Pfizer and Moderna to add myocarditis and pericarditis to their list of clinically significant adverse drug reactions (ADRs).
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Re: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Health ministry warns of vaccine's side effects

Saturday, Dec. 4, 1:01


https://www3.nhk.or.jp/nhkworld/en/news/20211204_12/


Japan's health ministry has listed inflammation of the heart muscle and of the outer lining of the heart in younger males as possible serious side effects of the Moderna and Pfizer COVID vaccines.


It says that as of November 14, out of every one million males who had the Moderna vaccine, such side effects were reported in 81.79 males aged 10 to 19 and 48.76 males in their 20s.

The figures were 15.66 and 13.32 respectively for those who had the Pfizer vaccine.

The ministry held a panel of expert on Saturday and proposed warning of the risk by printing "serious side effects" on the documents attached to the vaccines.

It will also require hospitals to report in detail incidents involving people who developed the symptoms within 28 days after being vaccinated, according to the law.

The plan was approved by the panel, and the ministry will notify municipalities.
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Re: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military

June 29, 2021


https://jamanetwork.com/journals/jamaca ... le/2781601
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Re: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Article Makes Unfounded Claims Linking Athletes’ Injuries, Deaths to Vaccines

By Saranac Hale Spencer, Brea Jones, Tess Hancock and Eugene Kiely

Posted on December 17, 2021

https://www.factcheck.org/2021/12/scich ... -vaccines/

Deceptive Videos Used to Link Athlete Deaths to COVID Shots

Jake West was a seemingly healthy 17-year-old before he collapsed during football practice and died of sudden cardiac arrest.
By Associated Press

Dec. 17, 2021, at 6:44 p.m.

https://www.usnews.com/news/health-news ... ovid-shots
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Re: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Fact Check-List of ‘108 FIFA soccer players’ is not proof of a common link between COVID-19 vaccines and athlete deaths

https://www.reuters.com/article/factche ... SL1N2T81NY
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Re: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

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Athletes are collapsing with heart-related issues due to the COVID-19 vaccines

https://www.politifact.com/factchecks/2 ... sing-heal/
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