TSOI News 11-1-2021

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Codycrusher
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Re: TSOI News 11-1-2021

Post by Codycrusher »

So is your thoughts basically, have the impactful and big PR’s on the Broker houses and the simple stuff just goes on everything else, non broker houses. Your in charge, I know you know what’s best.😄
Also for the record, it’s not just TSOI that gets bashed, almost every single company on earth whether they are doing good or not, all company’s have trolls and bashers so no way around it.
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TimGDixon
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Re: TSOI News 11-1-2021

Post by TimGDixon »

I never said that either. I find it very curious that we released news about about a new antibody to treat lung fibrosis due to covid-19 and we are having this discussion? I disagree with your "for the record" statement.
Codycrusher wrote: Mon Nov 01, 2021 1:30 pm So is your thoughts basically, have the impactful and big PR’s on the Broker houses and the simple stuff just goes on everything else, non broker houses. Your in charge, I know you know what’s best.😄
Also for the record, it’s not just TSOI that gets bashed, almost every single company on earth whether they are doing good or not, all company’s have trolls and bashers so no way around it.
tempo
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Re: TSOI News 11-1-2021

Post by tempo »

Hi Tim, first want to start off by saying today’s PR is awesome and thank you for all you do! In regards to the PR’s, to be honest, people that are not currently invested with TSOI wouldn’t see them anyway unless they were aired on national media. I know you’ll be making some really big news that everyone will see when the time is right! Thanks again Tim!! You Rock!
DebG53
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Re: TSOI News 11-1-2021

Post by DebG53 »

Tim, you don't owe ANYBODY an explanation about how and to whom you release information. No one but you and your team understand all that goes on behind the scenes. I- along with the majority of your stockholders- have the utmost confidence in you. Most of us are just waiting patiently for all of your work to come to fruition, whenever that may be. Most of us wouldn't even attempt to offer you advice on anything you are doing.... we trust that you are way smarter than we are! :D After all.... you've made it this far without our input!

Just keep on keeping on, my friend, and know that we believe in you and the process.

Best to you as always.

Debbie
Be Blessed, everyone. The future looks great.
Debbie
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TimGDixon
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Re: TSOI News 11-1-2021

Post by TimGDixon »

Thanks Tempo and you are correct - press releases from us are meant to do one thing - comply with the law. The law says if I have a material event I have 3 days to tell you about it. Filing a patent is a material event. Technically I could simply file an 8K with an exhibit that says everything I said in presser and I would be in full compliance. However I think you deserve some window dressing and thats all these news services are, window dressing, with distribution. I file an 8K and within minutes it will be on twitter and everywhere else and people could get the same info they do now. So I appreciate what you had to say.
tempo wrote: Mon Nov 01, 2021 1:49 pm Hi Tim, first want to start off by saying today’s PR is awesome and thank you for all you do! In regards to the PR’s, to be honest, people that are not currently invested with TSOI wouldn’t see them anyway unless they were aired on national media. I know you’ll be making some really big news that everyone will see when the time is right! Thanks again Tim!! You Rock!
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TimGDixon
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Re: TSOI News 11-1-2021

Post by TimGDixon »

Thank you Debbie - you always seem to brighten up the room and always say the nicest things and thats very kind of you. We have a very bright future that is full of really cool things, this is our lives at TSOI, this is who we are, this is what we do, and I know we are a little unorthodox and don't tend to follow the trend lines, but one day we will look back and say well wasn't that something.
DebG53 wrote: Mon Nov 01, 2021 2:08 pm Tim, you don't owe ANYBODY an explanation about how and to whom you release information. No one but you and your team understand all that goes on behind the scenes. I- along with the majority of your stockholders- have the utmost confidence in you. Most of us are just waiting patiently for all of your work to come to fruition, whenever that may be. Most of us wouldn't even attempt to offer you advice on anything you are doing.... we trust that you are way smarter than we are! :D After all.... you've made it this far without our input!

Just keep on keeping on, my friend, and know that we believe in you and the process.

Best to you as always.

Debbie

trustspecialist
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Re: TSOI News 11-1-2021

Post by trustspecialist »

Will this antibody be the subject of a future trial with COVID or will it be used concurrently in the planned Phase 3 study. I am just wondering how this will fit in with the rest of the therapeutic trials being developed by TSOI. In other words how will this fit exactly in the grand scheme of clinical trials for COVID? Sorry not explaining myself well so I apologize - this is all very exciting just wondering how it fits in if you can mention or elaborate on such.

Best

Scott
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TimGDixon
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Re: TSOI News 11-1-2021

Post by TimGDixon »

Abstract to today's patent is now online https://therapeuticsolutionsint.com/patent-abstracts/ but i place below for your convenience.

What we are calling TSOI-576 is one of several antibodies in this patent that are capable of facilitating interaction between an immune regulatory cell (NK, Th2, Th3, T reg) and a pulmonary epithelial progenitor cell(stem cell). This makes the antibody bispecific. So in simple terms we are using the antibody to enable cellular communications between immune regulatory and regenerative cells cells that are already present they just need to be called into action. The immune cells trigger morphogenesis so that the lung produces pulmonary epithelial progenitor cells to repair itself.

The future of course is clinical trials but I can't give you any guidance there right now.

Induction of Concurrent Pulmonary Immune Modulation and Regeneration by Protein Mediated Conjugation of Immune Regulatory Cells with Endogenous Progenitor Cells
Disclosed are means, methods and compositions of matter useful for treatment of inflammatory pulmonary diseases such as COVID-19 through administration of agents that facilitate interaction between immune modulatory cells and endogenous pulmonary progenitor cells. In one embodiment a bispecific antibody capable of facilitating the interaction between CD25 on T regulatory cells and CD47 on pulmonary epithelial stem cells is described.
curncman
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Re: TSOI News 11-1-2021

Post by curncman »

Thanks for being elaborative on todays NEWS on the patent! So I understand that JADICELLS have the bispecific nature allows the LUNG regeneration right ? So this will lead TSOI into NEW CLINICAL TRIAL in addition to the Phase 3 Phase2 CTE trial (presently in IND status)? thx again
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TimGDixon
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Re: TSOI News 11-1-2021

Post by TimGDixon »

No this is not JadiCell. This is an antibody that can stimulate the immune system to depress inflammation and repair tissue by forcing the lung to produce stem cells.
curncman wrote: Mon Nov 01, 2021 3:28 pm Thanks for being elaborative on todays NEWS on the patent! So I understand that JADICELLS have the bispecific nature allows the LUNG regeneration right ? So this will lead TSOI into NEW CLINICAL TRIAL in addition to the Phase 3 Phase2 CTE trial (presently in IND status)? thx again
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