Suicide/CTE need

This forum is to discuss general things concerning TSOI.
trader32176
Posts: 3858
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Re: Suicide/CTE need

Post by trader32176 »

Concussions, and repeated concussions,and head trauma from car accidents, all contact sports, w/ repeated concussions then as knowledge increased there was what we know as blast induced concussions . these concussions from mortar, cannon, and IED blasts - very few want to engage in a discussion about blast concussions leading to CTE/TBI .
Been there , done that . no one ever replied to this issue.
and I hope some will add their real life experences here with their actual blast concussion stories.

the list of the blasted goes on


Combat Veterans and Special Forces
SEAL TEAMS / Underwater demolition
SWAT Teams
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Underwater divers
Fireworks Technicians
DebG53
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Location: Central Florida

Re: Suicide/CTE need

Post by DebG53 »

Police officers also fall victim to suicidal thoughts. We live in the Tampa Bay area in Florida. We've had so many officers take their lives. About three years ago a friend of ours from the sheriff's department shot and killed his wife, went to his daughter's house shot and killed her and her very young daughter, then went across the street to the high school and took his life in the parking lot. It was horrific! We had just seen he and his wife at a fall festival a couple of weeks prior. He seemed fine, normal.

We truly never know what is going on in someone else's mind. That's why we should always choose kindness. Always.

Debbie
Be Blessed, everyone. The future looks great.
Debbie
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TimGDixon
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Re: Suicide/CTE need

Post by TimGDixon »

Suicide and suicidal ideation affects for more people than most ever imagine. Here is what we do know. We have been able to identify with great sensitivity and specificity certain proteins present in someone's blood that correlates to propensity to commit suicide even before they have had the thoughts and even when they are hiding the thoughts. This changes everything. Everything we have been doing over the last 7 or 8 years has led us here, to the brain. Our goal is to have that blood test readily available to psychiatrists once we complete phase 3. I am not the CEO of Campbell so I don't want to speak about too much they are doing but its very cutting edge.
DebG53 wrote: Mon Jan 10, 2022 9:25 am Police officers also fall victim to suicidal thoughts. We live in the Tampa Bay area in Florida. We've had so many officers take their lives. About three years ago a friend of ours from the sheriff's department shot and killed his wife, went to his daughter's house shot and killed her and her very young daughter, then went across the street to the high school and took his life in the parking lot. It was horrific! We had just seen he and his wife at a fall festival a couple of weeks prior. He seemed fine, normal.

We truly never know what is going on in someone else's mind. That's why we should always choose kindness. Always.

Debbie
MajikMann
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Joined: Wed Jun 30, 2021 10:14 am
Location: Michigan

Re: Suicide/CTE need

Post by MajikMann »

Tim,

I know you and your team (and Campbell) are working on this aspect and appreciate that. I posted this for the awareness of some of our newer forum members who may not know how involved the family of companies are in this area

Best, Dave
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TimGDixon
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Re: Suicide/CTE need

Post by TimGDixon »

Thanks Dave. We are all living and working through an age of great discovery. Its not that we just have a diagnostic here - we have an entire suite of immunotherapies Tom and I developed that go along with it.

Suicide is a Major Problem: In 2017, in the USA, suicide was the second leading cause of death among individuals between the ages of 10 and 34, with twice as many suicides as there were homicides [1]. Suicide is significantly more prevalent in veterans, in which approximately 20 deaths per day occur [2].

New Approaches are Needed: Psychotherapy and current drug interventions have not significantly reduced the rate of suicide. In fact, suicide rates have increased approximately 60% since 1981 [3].

Suicide is not only Mental: Suicidal ideation and suicide have been associated with inborn genetic components [4] as well as various forms of inflammation that occur as a result of brain injury [5]. In some situations, depression or other pathological mental states have been shown to induce inflammation [6], which is subsequently associated with suicidal ideation and suicide [7].

Inflammation is a Major Cause of Suicide: Molecular signals which in healthy individuals are associated with the body fighting disease, such as TNF-alpha, are turned on by the brain when they are needed, and turned off when the disease has been defeated. In patients with suicidal ideation, these signals are turned on at a low level without being turned off. It is known that these “inflammatory signals”, otherwise known as “inflammatory cytokines” are associated with depression based human studies in which inflammatory signals were artificially manufactured and administered in patients to fight cancer and treated patients became depressed [8]. Additionally, studies show that patients who are successfully treated for depression have a reduction in inflammatory signals in the blood [9, 10]. Furthermore, various cofactors known to increase suicide rates such as drug abuse [11], alcoholism [12], and brain injury [13], have been shown to increase inflammatory signaling.

Diagnosis
1. Analysis of what is happening in blood. Proprietary algorithm utilizing already available blood tests to establish patients at risk of suicide (Doctor or rehab facility sends to us lab results from Quest and we plug into our computer and give risk score)
2. Analysis of what is happening in brain. Brain produces very small particles called exosomes that we can isolate, and they tell us how much inflammation is happening specifically in brain. Additionally, when appropriate, imaging studies using fMRI and various dyes to detect specific areas of brain atrophy and/or inflammation
3. Analysis of what is happening in the gut. Analysis of the microbiome in gut suggests overall inflammation in body
4. Analysis of suicide associated gene. Several gene polymorphisms have been shown to be associated with suicide.

The above physical findings are utilized to develop a suicide risk score, as well as to establish a baseline for intervention. In some situations physicians will only be interested in attaining our suicide risk score and they will perform their own interventions. We are the only group to have developed a suicide risk score based on medical and not psychological findings.

Intervention
1. Clinical trial of QuadraMune™, clinically validated to reduces biomarkers associated with suicide risk
2. Broad acting anti-inflammatory natural interventions. Intravenous vitamin C, vitamin D, fish oil, quercetin, micronutrients.
3. Specific anti-inflammatory antibodies. Anti-TNF, anti-IL-17, anti-IL21
4. Microbiome modulators. Probiotics, prebiotics, fecal transplants
5. Cell based therapies. Autologous bone marrow
6. Transcranial Magnetic Stimulation. Various studies have shown ability to reduce neural inflammation and augment brain regeneration using this approach.

Action Plan
1. Understanding intellectual property landscape around our broad ideas of diagnosis and treatment. Filing new patents and/or licensing.
2. Creation of a “Central Core” which analyzes data and provides patient specific recommendations together with the input from the health care professional
3. Selling subscriptions to medical professionals, drug rehab clinics, etc.

References:

[1] https://www.nimh.nih.gov/health/statist ... art_154968
[2] https://www.mentalhealth.va.gov/docs/20 ... report.pdf
[3] https://webappa.cdc.gov/sasweb/ncipc/mortrate.html
[4] https://www.sciencedaily.com/releases/2 ... 113941.htm
[5] Juengst et al. Exploratory associations with tumor necrosis factor-α, disinhibition and suicidal endorsement after traumatic brain injury. Brain Behav Immun. 2014 Oct;41:134-43.
[6] Zhu et al. Neuroinflammation caused by mental stress: the effect of chronic restraint stress and acute repeated social defeat stress in mice. Neurol Res. 2019 Aug;41(8):762-769
[7] O'Donovan et al. Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder. Depress Anxiety. 2013 Apr;30(4):307-14.
[8] Illman et al. Are inflammatory cytokines the common link between cancer-associated cachexia and depression? J Support Oncol. 2005 Jan-Feb;3(1):37-50.
[9] Lanquillon et al. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology. 2000 Apr;22(4):370-9.
[10] Chen et al. Rapid inflammation modulation and antidepressant efficacy of a low-dose ketamine infusion in treatment-resistant depression: A randomized, double-blind control study. Psychiatry Res. 2018 Nov;269:207-211.
[11] Kapasi et al. Morphine stimulates mesangial cell TNF-alpha and nitrite production. Inflammation. 2000 Oct;24(5):463-76.
[12] Valles et al. Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. Brain Pathol. 2004;14:365–371.
[13] Yang et al. Serum macrophage migration inhibitory factor concentrations correlate with prognosis of traumatic brain injury. Clin Chim Acta. 2017 Jun;469:99-104.
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