Can Always Ask Tim

This forum is to discuss general things concerning TSOI.
User avatar
TimGDixon
Posts: 3234
Joined: Fri Jun 26, 2020 4:36 am
Location: The Bunker

Re: Can Always Ask Tim

Post by TimGDixon »

You got it.
A2Z wrote: Wed Jan 05, 2022 8:43 am Tim yes i would like to try a sample bottle of nanotillbene that you offered. You already have my mailing info as i have been on quadramune for the last 2-3 months.

I want to thank you very much for the offer
curiousman
Posts: 28
Joined: Fri Dec 24, 2021 3:09 am

Re: Can Always Ask Tim

Post by curiousman »

TimGDixon wrote: Tue Jan 04, 2022 5:26 pm At this point we haven't looked at that specifically. We employ peptides broadly in lots of our IP - if you browse this stemvacs patent you will find ample discussion on how we use peptides to create antigens to things like sars/cov2, cancer, etc. https://patents.justia.com/patent/20210393681
4realz wrote: Tue Jan 04, 2022 5:10 pm Tim,

Ran across an interesting peptide study on Covid .. I am curious .. any sort of study in herpetic patients on Quadramune? .. i am not qualified enough to put two and two together but I see references to peptides and IL this and IL that .. when I find studies along the same lines often wonder if you’ve seen any effects .. one would surmise if a treatment is effective on a virus like Covid it may be possible to treat others and visa versa.. talk about a huge virtually untapped market. Now Alyclovir? And resistance to …. Which is how i found this article .. the thought of Alcyclovir treating Covid led me to this peptide convo and now off on the tangent of Quadramune in other viral suppression. Any evidence of efficacy there; suppression of the herpes virus?

https://www.acs.org/content/acs/en/pres ... erpes.html


“In the body, antimicrobial peptides such as LL-37 help keep viruses, bacteria, fungi, cancer cells and even parasites under control,” says Annelise Barron, Ph.D


MB1972 wrote: Thu Sep 16, 2021 2:33 pm Tim, with tdy's news on QM along w/ ivermectin is there any interest in using QM with other therapies which seem to help the reduce lung inflammation/ cytokine storms which seems to be the cause of ppl entering the hospital/ ICU .. Ive read about two in particular Aviptadil ( a natural peptide which has a 20 yr history of safety) and Bucillamine ( which is currently used for arthritis in Japan& Korea) Aviptadil is currently phase 3 awaiting EUA for Covid use ... Only by IV in hospital setting..Buci ( also in phase3) is in a pill form so it could be used along w/QM for CV2 use.. Just a thought
Ah the LL-37 protein! Yes in Neil Riordan's book "Stem cell therapy: a rising tide" he spoke about it, I'm not sure if he called it a peptide I think he called it "LL-37 protein" but proteins and peptides are the same thing right? Neil Riordan spoke at length about how umbilical cord MSCs secrete a protein when in the presence of bacteria, and this protein is one of the most powerful antibacterial substances in all of nature, the LL-37 protein. So essentially UC-MSCs can also be used to kill a bacterial infection.

Neil gives you a great example in his amazing book. Bernie Marcus is the billionaire founder of Home Depot (I mean who hasn't shopped at Home Depot right?), Bernie had Bronchiectasis caused by a chronic bacterial infection of his lungs, since Bernie is kinda famous he will give talks, but he was having a hard time speaking because he'd cough a dozen times or more per hour, and it was getting worse so something had to be done. The doctors told Bernie that it would take 2 years of antibiotics to cure it, which would have unpleasant side effects on his digestion system (think about it there are bacteria that live in your gut that are essential to your health but antibiotics kill all bacteria indiscriminately). So Bernie flew down to Panama to get treated with UC-MSCs on his physician's recommendation.

After Bernie Marcus got an infusion of UC-MSCs his symptoms improved by 90% and his doctors in the USA tested him and were astonished to find that the bacteria in his lungs could barely be detected, which is pretty much unheard of when you have Bronchiectasis. So because of this Bernie flew his wife down to Panama to get both of her knees injected with stem cells, her doctors said both of her knees would have to be replaced which would have put her out of action for 1 whole year. Just three weeks later she was back to playing golf 4 times a week, when prior to getting the stem cells she couldn't walk because of the pain in her knees. And of course Bernie told his friends about what happened and so they flew down to Panama for stem cells for their back pain which cured their back pain, now pay attention, Bernie's friends prior to getting UC-MSCs in Panama, had gotten surgery here in America for their backs which made it even worse! Because in the American healthcare system when you go complaining to your doctor about back pain that just won't go away they'll often times recommend surgery, which of course is going to make it worse, your back is not designed to be cut open and sliced at with a scalpel, but that's how the American healthcare system currently works. Can you imagine the day when you go to your doctor and complain about back pain and they say "Well sounds like you need umbilical cord MSCs."

I mean I'm just blown away by the potential of umbilical cord MSCs, what can't they do?

I am convinced that umbilical cord MSCs are going to revolutionize our healthcare system, we just need to get it out there into the real world and get people treated. I can't wait for the phase 3 trial to commence!
User avatar
TimGDixon
Posts: 3234
Joined: Fri Jun 26, 2020 4:36 am
Location: The Bunker

Re: Can Always Ask Tim

Post by TimGDixon »

On a whole UC-MSC's are incredible because 1) they are considered adult and 2) undergo adipogenic ,osteogenic, chondrogenic and cardiogenic differentiation. No you can't form placenta or umbilical cord but from bone to blood cells is pretty amazing. JadiCells refine the class of cells into a very potent msc that has been used over the years for a wide variety of application. JadiCells were the first msc's ever injected in the human heart by the inventor himself a renown cardio/thoracic surgeon, amit patel. Patel, Ichim, Riordan have published together for a very long time. Here is a short list of papers they've published together.
I mean I'm just blown away by the potential of umbilical cord MSCs, what can't they do?

I am convinced that umbilical cord MSCs are going to revolutionize our healthcare system, we just need to get it out there into the real world and get people treated. I can't wait for the phase 3 trial to commence!
Ichim TE, Alexandrescu DT, Solano F, Lara F, Campion Rde N, Paris E, Woods
EJ, Murphy MP, Dasanu CA, Patel AN, Marleau AM, Leal A, Riordan NH. Mesenchymal
stem cells as anti-inflammatories: implications for treatment of Duchenne
muscular dystrophy. Cell Immunol. 2010;260(2):75-82. doi:
10.1016/j.cellimm.2009.10.006. PMID: 19917503.

Mikirova NA, Jackson JA, Hunninghake R, Kenyon J, Chan KW, Swindlehurst CA,
Minev B, Patel AN, Murphy MP, Smith L, Alexandrescu DT, Ichim TE, Riordan NH.
Circulating endothelial progenitor cells: a new approach to anti-aging medicine?
J Transl Med. 2009 Dec 15;7:106. doi: 10.1186/1479-5876-7-106. PMID: 20003528;
PMCID: PMC2804590.

Riordan NH, Ichim TE, Min WP, Wang H, Solano F, Lara F, Alfaro M, Rodriguez
JP, Harman RJ, Patel AN, Murphy MP, Lee RR, Minev B. Non-expanded adipose
stromal vascular fraction cell therapy for multiple sclerosis. J Transl Med.
2009 Apr 24;7:29. doi: 10.1186/1479-5876-7-29. PMID: 19393041; PMCID:
PMC2679713.

Murphy MP, Wang H, Patel AN, Kambhampati S, Angle N, Chan K, Marleau AM,
Pyszniak A, Carrier E, Ichim TE, Riordan NH. Allogeneic endometrial regenerative
cells: an "Off the shelf solution" for critical limb ischemia? J Transl Med.
2008 Aug 19;6:45. doi: 10.1186/1479-5876-6-45. PMID: 18713449; PMCID:
PMC2533293.

Ichim TE, Solano F, Lara F, Rodriguez JP, Cristea O, Minev B, Ramos F, Woods
EJ, Murphy MP, Alexandrescu DT, Patel AN, Riordan NH. Combination stem cell
therapy for heart failure. Int Arch Med. 2010 Apr 14;3(1):5. doi:
10.1186/1755-7682-3-5. PMID: 20398245; PMCID: PMC3003238.

Ichim TE, Zhong Z, Mikirova NA, Jackson JA, Hunninghake R, Mansilla E, Marín
G, Núñez L, Patel AN, Angle N, Murphy MP, Dasanu CA, Alexandrescu DT, Bogin V,
Riordan NH. Circulating endothelial progenitor cells and erectile dysfunction:
possibility of nutritional intervention? Panminerva Med. 2010 Jun;52(2 Suppl
1):75-80. PMID: 20657539.

Riordan NH, Madrigal M, Reneau J, de Cupeiro K, Jiménez N, Ruiz S, Sanchez
N, Ichim TE, Silva F, Patel AN. Scalable efficient expansion of mesenchymal stem
cells in xeno free media using commercially available reagents. J Transl Med.
2015 Jul 17;13:232. doi: 10.1186/s12967-015-0561-6. PMID: 26183703; PMCID:
PMC4504159.

Han X, Meng X, Yin Z, Rogers A, Zhong J, Rillema P, Jackson JA, Ichim TE,
Minev B, Carrier E, Patel AN, Murphy MP, Min WP, Riordan NH. Inhibition of
intracranial glioma growth by endometrial regenerative cells. Cell Cycle. 2009
Feb 15;8(4):606-10. doi: 10.4161/cc.8.4.7731. Epub 2009 Mar 2. PMID: 19197154.

Zhong Z, Patel AN, Ichim TE, Riordan NH, Wang H, Min WP, Woods EJ, Reid M,
Mansilla E, Marin GH, Drago H, Murphy MP, Minev B. Feasibility investigation of
allogeneic endometrial regenerative cells. J Transl Med. 2009 Feb 20;7:15. doi:
10.1186/1479-5876-7-15. PMID: 19232091; PMCID: PMC2649897.

Mikirova NA, Jackson JA, Hunninghake R, Kenyon J, Chan KW, Swindlehurst CA,
Minev B, Patel AN, Murphy MP, Smith L, Ramos F, Ichim TE, Riordan NH.
Nutraceutical augmentation of circulating endothelial progenitor cells and
hematopoietic stem cells in human subjects. J Transl Med. 2010 Apr 8;8:34. doi:
10.1186/1479-5876-8-34. PMID: 20377846; PMCID: PMC2862021.

Mansilla E, Spretz R, Larsen G, Nuñez L, Drago H, Sturla F, Marin GH, Roque
G, Martire K, Díaz Aquino V, Bossi S, Gardiner C, Lamonega R, Lauzada N, Cordone
J, Raimondi JC, Tau JM, Biasi NR, Marini JE, Patel AN, Ichim TE, Riordan N,
Maceira A. Outstanding survival and regeneration process by the use of
intelligent acellular dermal matrices and mesenchymal stem cells in a burn pig
model. Transplant Proc. 2010 Dec;42(10):4275-8. doi:
10.1016/j.transproceed.2010.09.132. PMID: 21168681.

Ichim TE, Alexandrescu DT, Solano F, Lara F, Campion Rde N, Paris E, Woods
EJ, Murphy MP, Dasanu CA, Patel AN, Marleau AM, Leal A, Riordan NH. Mesenchymal
stem cells as anti-inflammatories: implications for treatment of Duchenne
muscular dystrophy. Cell Immunol. 2010;260(2):75-82. doi:
10.1016/j.cellimm.2009.10.006. PMID: 19917503.

Mikirova NA, Jackson JA, Hunninghake R, Kenyon J, Chan KW, Swindlehurst CA,
Minev B, Patel AN, Murphy MP, Smith L, Alexandrescu DT, Ichim TE, Riordan NH.
Circulating endothelial progenitor cells: a new approach to anti-aging medicine?
J Transl Med. 2009 Dec 15;7:106. doi: 10.1186/1479-5876-7-106. PMID: 20003528;
PMCID: PMC2804590.

Riordan NH, Ichim TE, Min WP, Wang H, Solano F, Lara F, Alfaro M, Rodriguez
JP, Harman RJ, Patel AN, Murphy MP, Lee RR, Minev B. Non-expanded adipose
stromal vascular fraction cell therapy for multiple sclerosis. J Transl Med.
2009 Apr 24;7:29. doi: 10.1186/1479-5876-7-29. PMID: 19393041; PMCID:
PMC2679713.

Wagner SC, Riordan NH, Ichim TE, Szymanski J, Ma H, Perez JA, Lopez J, Plata-
Munoz JJ, Silva F, Patel AN, Kesari S. Safety of targeting tumor endothelial
cell antigens. J Transl Med. 2016 Apr 12;14:90. doi: 10.1186/s12967-016-0842-8.
PMID: 27071457; PMCID: PMC4830034.
trustspecialist
Posts: 47
Joined: Sat Aug 28, 2021 3:18 pm

Re: Can Always Ask Tim

Post by trustspecialist »

Hi Tim

I know you have answered this before but where can one order Quadramune and get it very quickly. I checked on Amazon and it takes until 1/26 to receive. I checked on you can order now website but it doesn’t give the cost of the product when you are placing the order. Sorry I see it now $68 so I answered my own question...just wanted to be ready if needed...Thanks

Best

Scott
User avatar
TimGDixon
Posts: 3234
Joined: Fri Jun 26, 2020 4:36 am
Location: The Bunker

Re: Can Always Ask Tim

Post by TimGDixon »

Yeah Amazon is whacked at the moment - it was March 11 two days ago.
trustspecialist wrote: Sun Jan 09, 2022 1:21 pm Hi Tim

I know you have answered this before but where can one order Quadramune and get it very quickly. I checked on Amazon and it takes until 1/26 to receive. I checked on you can order now website but it doesn’t give the cost of the product when you are placing the order. Sorry I see it now $68 so I answered my own question...just wanted to be ready if needed...Thanks

Best

Scott
DebG53
Posts: 140
Joined: Mon Sep 27, 2021 12:23 pm
Location: Central Florida

Re: Can Always Ask Tim

Post by DebG53 »

Scott,

Don't forget discount code James for 10% discount! (Hope I got to you in time!)

Debbie



trustspecialist wrote: Sun Jan 09, 2022 1:21 pm Hi Tim

I know you have answered this before but where can one order Quadramune and get it very quickly. I checked on Amazon and it takes until 1/26 to receive. I checked on you can order now website but it doesn’t give the cost of the product when you are placing the order. Sorry I see it now $68 so I answered my own question...just wanted to be ready if needed...Thanks

Best

Scott
Be Blessed, everyone. The future looks great.
Debbie
trustspecialist
Posts: 47
Joined: Sat Aug 28, 2021 3:18 pm

Re: Can Always Ask Tim

Post by trustspecialist »

Thanks Debbie I’ll keep this in mind
curiousman
Posts: 28
Joined: Fri Dec 24, 2021 3:09 am

Re: Can Always Ask Tim

Post by curiousman »

Tim you are the one whose literally on the cutting edge of the science behind MSCs. Are there any mind blowing facts you can share with us about MSCs? Anything crazy interesting that they've discovered about MSCs recently?
User avatar
TimGDixon
Posts: 3234
Joined: Fri Jun 26, 2020 4:36 am
Location: The Bunker

Re: Can Always Ask Tim

Post by TimGDixon »

curiousman wrote: Sat Jan 15, 2022 10:39 am Tim you are the one whose literally on the cutting edge of the science behind MSCs. Are there any mind blowing facts you can share with us about MSCs? Anything crazy interesting that they've discovered about MSCs recently?
Sars/CoV2 has provided us an opportunity to look at MSC's in ways that may not have occurred otherwise. As bad as it has been it has been very good to our own drug development.

In 2004 Brinkmann et al published a bizarre observation: that upon specific activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. They termed these strange fibers neutrophil extracellular traps (NETs). The researchers found that NETs degrade virulence factors and kill bacteria. Furthermore, they observed that NETs are abundant in vivo in experimental dysentery and spontaneous human appendicitis, two examples of acute inflammation. In the paper the researchers concluded that NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria [1].

It is known that neutrophils, in part due to their differentiated nature and relatively short half-life, are primarily transcriptionally inactive and their DNA is condensed into heterochromatin within the nucleus [2-7]. As with other cells, in the neutrophil nucleosome is composed of DNA that is wrapped around histones. The nucleosomes are further organized into chromatin. For the heterochromatin to open, that is, “decondense” then enzyme peptidyl arginine deiminase 4 (PAD4) is critical because it catalyzes the conversion of histone arginines to citrullines, thus reducing the strong positive charge of histones and consequently weakening histone-DNA binding [8-18]. This reduced interaction permits for the unravelling of the nucleosomes, which is essential for NET formation. Rapid increases in intracellular Ca2+ are needed for intracellular signal transduction during normal neutrophil activation [19-30]

It is known that COVID-19 pathology is caused in many cases by lung inflammation. There are numerous components that are in some cases causative and in some cases associated with the lung damage. We discovered that by suppressing neutrophil release of NETs as well as by inactivating NETs, we are able to reduce COVID-19 pathology with JadiCells.

NETs have been described in numerous conditions associated with COVID-19. For example, one of the first suggestions of NETs playing a lethal role in COVID-19 infection was an autopsy report published in the Journal of Translational Medicine describing histones and neutrophils that appeared to have released their NETs in the lungs of a patient who succumbed to disease [31].

So here is one new thing about MSC's, they are a means of generating neonatal NETS inhibiting factor, or compounds similar to it, or through the use of other regenerative cells. The reduction of neutrophil extracellular traps accomplished by administration of JadiCells and/or MSC derivatives could be utilized to reduce expansion of aneurysms such as aortic aneurysms [32].

1. Brinkmann, V., et al., Neutrophil extracellular traps kill bacteria. Science, 2004. 303(5663): p. 1532-5.
2. Zhu, Y., et al., Comprehensive characterization of neutrophil genome topology. Genes Dev, 2017. 31(2): p. 141-153.
3. Dumler, J.S., et al., Genome-Wide Anaplasma phagocytophilum AnkA-DNA Interactions Are Enriched in Intergenic Regions and Gene Promoters and Correlate with Infection-Induced Differential Gene Expression. Front Cell Infect Microbiol, 2016. 6: p. 97.
4. Lukasova, E., et al., Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes. Biochim Biophys Acta, 2013. 1833(3): p. 767-79.
5. Smetana, K., D. Mikulenkova, and H. Klamova, Heterochromatin density (condensation) during cell differentiation and maturation using the human granulocytic lineage of chronic myeloid leukaemia as a convenient model. Folia Biol (Praha), 2011. 57(5): p. 216-21.
6. Olin, A.L., et al., The human granulocyte nucleus: Unusual nuclear envelope and heterochromatin composition. Eur J Cell Biol, 2008. 87(5): p. 279-90.
7. Grigoryev, S.A. and C.L. Woodcock, Chromatin structure in granulocytes. A link between tight compaction and accumulation of a heterochromatin-associated protein (MENT). J Biol Chem, 1998. 273(5): p. 3082-9.
8. Cooper, P.R., L.J. Palmer, and I.L. Chapple, Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe? Periodontol 2000, 2013. 63(1): p. 165-97.
9. Sur Chowdhury, C., et al., Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility. Arthritis Res Ther, 2014. 16(3): p. R122.
10. Leppkes, M., et al., Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis. Nat Commun, 2016. 7: p. 10973.
11. Ghari, F., et al., Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response. Sci Adv, 2016. 2(2): p. e1501257.
12. Vollger, L., et al., Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils. Biosci Rep, 2016. 36(3).
13. Yost, C.C., et al., Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. J Clin Invest, 2016. 126(10): p. 3783-3798.
14. Zepeda-Mendoza, C.J., et al., Phenotypic interpretation of complex chromosomal rearrangements informed by nucleotide-level resolution and structural organization of chromatin. Eur J Hum Genet, 2018. 26(3): p. 374-381.
15. Agraz-Cibrian, J.M., D.M. Giraldo, and S. Urcuqui-Inchima, 1,25-Dihydroxyvitamin D3 induces formation of neutrophil extracellular trap-like structures and modulates the transcription of genes whose products are neutrophil extracellular trap-associated proteins: A pilot study. Steroids, 2019. 141: p. 14-22.
16. Gosswein, S., et al., Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation. Front Immunol, 2019. 10: p. 2481.
17. Beato, M. and P. Sharma, Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer. Int J Mol Sci, 2020. 21(4).
18. Shi, L., et al., Endogenous PAD4 in Breast Cancer Cells Mediates Cancer Extracellular Chromatin Network Formation and Promotes Lung Metastasis. Mol Cancer Res, 2020. 18(5): p. 735-747.
19. Okochi, Y. and Y. Okamura, Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels. Int J Mol Sci, 2021. 22(5).
20. Serov, D., et al., Calcium activity in response to nAChR ligands in murine bone marrow granulocytes with different Gr-1 expression. Cell Biol Int, 2021. 45(7): p. 1533-1545.
21. Zhai, T.Y., et al., Exosomes Released from CaSR-Stimulated PMNs Reduce Ischaemia/Reperfusion Injury. Oxid Med Cell Longev, 2021. 2021: p. 3010548.
22. Singh, P.K., et al., Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone triggers mitochondrial dysfunction and apoptosis in neutrophils through calcium signaling. Med Microbiol Immunol, 2019. 208(6): p. 855-868.
23. Gorudko, I.V., et al., Neutrophil activation in response to monomeric myeloperoxidase. Biochem Cell Biol, 2018. 96(5): p. 592-601.
24. Chen, C.Y., et al., Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium. Sci Rep, 2015. 5: p. 18204.
25. Herrmann, J.M. and J. Meyle, Neutrophil activation and periodontal tissue injury. Periodontol 2000, 2015. 69(1): p. 111-27.
26. Conejeros, I., et al., Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils. Dev Comp Immunol, 2015. 52(2): p. 215-25.
27. Hallett, M.B., M. Al-Jumaa, and S. Dewitt, Optical methods for the measurement and manipulation of cytosolic calcium signals in neutrophils. Methods Mol Biol, 2014. 1124: p. 107-20.
28. Zhang, H., et al., STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood, 2014. 123(14): p. 2238-49.
29. Prufer, S., et al., Distinct signaling cascades of TREM-1, TLR and NLR in neutrophils and monocytic cells. J Innate Immun, 2014. 6(3): p. 339-52.
30. Kappala, S.S., et al., FMLP-, thapsigargin-, and H(2)O(2)-evoked changes in intracellular free calcium concentration in lymphocytes and neutrophils of type 2 diabetic patients. Mol Cell Biochem, 2014. 387(1-2): p. 251-60.
31. Barnes, B.J., et al., Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J Exp Med, 2020. 217(6).
32. Wei, M., et al., Inhibition of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation Reduces Angiotensin II-Induced Abdominal Aortic Aneurysm Rupture in Mice. Front Cardiovasc Med, 2021. 8: p. 676612.
Last edited by TimGDixon on Sat Jan 15, 2022 11:17 am, edited 1 time in total.
User avatar
TimGDixon
Posts: 3234
Joined: Fri Jun 26, 2020 4:36 am
Location: The Bunker

Re: Can Always Ask Tim

Post by TimGDixon »

Reduction of Neutrophil Extracellular Trap formation by Mesenchymal Stem Cells and their Exosomes

Disclosed are methods of reducing lung inflammation in acute respiratory distress syndrome elicited by various factors such as COVID-19 infection by reduction of neutrophil extracellular trap formation through administration of mesenchymal stem cells and/or exosomes thereof. The invention provides means of inhibiting neutrophil release of extracellular traps by mesenchymal stem cells and/or exosomes derived from said mesenchymal stem cells. Additionally, synergies are provided between mesenchymal stem cells and/or exosomes derived from mesenchymal stem cells and agents approaches which reduce neutrophil extracellular trap formation.
Post Reply