Diabetes and Covid 19

trader32176
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Re: Diabetes and Covid 19

Post by trader32176 »

“ While pharmaceutical treatments continue to evolve to contain the effects of the disease, sedentary lifestyle and unhealthy diets increase the diabetes population. Dietary supplementation is a robust add-on method to control the effects of diabetes without side-effect.”

It's time to revisit the info on NanoStilbene ,and dietary supplementation of NanoStilbene for obesity , and diabetes , and figure out how much dietary supplementation with NanoStibene has an effect on these issues , as well as considering these benefits in regard to Covid 19 .

After I do more study on this , I will post the results of my next search .
rrao11
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Re: Diabetes and Covid 19

Post by rrao11 »

Thanks for all the research Trader!
trader32176
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Re: Diabetes and Covid 19

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Pterostilbene Protects Cochlea from Ototoxicity in Streptozotocin-Induced Diabetic Rats by Inhibiting the Apoptosis
https://www.biorxiv.org/content/10.1101 ... 798v1.full

Diabetes mellitus (DM) is a common metabolic disorder that affects the metabolism of proteins, fats, and carbohydrates. DM is caused by the pancreas’s failure to secrete insulin and/or the deterioration of the tissue’s response to insulin.1 Globally, diabetes is currently projected to affect 425 million people, and that number that is expected to reach 629 million by 2045.2 Diabetes causes complications in many organs, such as the kidneys, liver, nervous system, reproductive system, and eyes.

In DM, metabolic stress and oxygen reduction have been shown to increase free oxygen radical production and to decrease the protective capacity of the antioxidant defense system.14 DM contributes to the development of complications such as blindness, heart-vessel disease, and kidney disease, leading to a series of cascade reactions that cause the excessive production of free radicals.

Sudden or gradual hearing loss has been observed in DM patients.4,5,9 DM has been reported to cause various histological changes and hearing loss in the cochlea, VIII nerve, and the temporal bone.

PTS decreased the cochlear damage caused by diabetes
, as confirmed by DPOAE, biochemical, histopathological, immunohistochemical, and molecular findings. This study reports the first in vivo findings to suggest that PTS may be a protective therapeutic agent against diabetes-induced ototoxicity.
trader32176
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Re: Diabetes and Covid 19

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Pterostilbene Prevents Early Diabetic Retinopathy Alterations in a Rabbit Experimental Model

https://pubmed.ncbi.nlm.nih.gov/31892189/

Oxidative stress generated by diabetes plays a key role in the development of diabetic retinopathy (DR), a common diabetic complication. DR remains asymptomatic until it reaches advanced stages, which complicate its treatment. Although it is known that good metabolic control is essential for preventing DR, knowledge of the disease is incomplete and an effective treatment with no side effects is lacking. Pterostilbene (Pter), a natural stilbene with good antioxidant activity, has proved to beneficially affect different pathologies, including diabetes. Therefore, our study aimed to analyse the protective and/or therapeutic capacity of Pter against oxidant damage by characterising early retinal alterations induced by hyperglycaemia, and its possible mechanism of action in a rabbit model of type 1 diabetes mellitus. Pter reduced lipid and protein oxidative damage, and recovered redox status and the main activities of antioxidant enzymes. Moreover, the redox regulation by Pter was associated with activation of the PI3K/AKT/GSK3β/NRF2 pathway. Our results show that Pter is a powerful protective agent that may delay early DR development.
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TimGDixon
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Re: Diabetes and Covid 19

Post by TimGDixon »

Great papers Trader - keep up the good digging. Maybe we should call you Digger Dan...
trader32176
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Re: Diabetes and Covid 19

Post by trader32176 »

Thanks Tim ,
Here is another one for everyone to read :


Suppressing cardiac oxidative stress and apoptosis via AMPK stimulation may represent a primary mechanism whereby pterostilbene attenuates diabetic myocardial IR injury.

Diabetes markedly alters the cardiac gene expression patterns of several metabolic, structural, signal transductions and stress response proteins, leading to the development of cardiac complications. These alterations accelerate the susceptibility of the heart muscle to myocardial ischemia-reperfusion (IR) injury [1, 2], resulting in poor clinical prognosis after myocardial infarction [3]. Moreover, diabetic patients have a higher risk of developing myocardial IR than non-diabetic subjects [4]. Therapeutic agents that alleviate myocardial IR injury in non-diabetic rodent models are mostly ineffective in reducing cardiac IR injury in diabetic animal models [5]. Since conventional antidiabetic therapies have severe limitations due to their adverse effects [6], it is essential to seek efficient antidiabetic drugs with negligible side effects to facilitate the treatment of myocardial IR injury in diabetes.

Adenosine monophosphate-activated protein kinase (AMPK) has emerged as a master regulator of metabolic energy, and is a cellular adaptive mechanism activated during metabolic stress to boost energy production and so that to salvage the failing myocardium [13, 14] and myocardial IR injury [15]. Of note, AMPK activation has been verified to confer cardioprotection against myocardial IR injury in diabetes by limiting cardiac apoptosis through attenuation of endoplasmic reticulum stress [14, 16]. Intriguingly, several AMPK activators such as metformin [17], trimetazidine [18], rosiglitazone [19] have been demonstrated to attenuate diabetic myocardial IR injury via AMPK stimulation.

However, the serious adverse effects like hypoglycemia, lactic acidosis and gastrointestinal disturbances associated with these drugs limited their therapeutic utility in diabetic patients .


Recent studies have shown that PT decreases lipogenesis and fat accumulation, promotes macroautophagy and inhibits apoptosis via AMPK stimulation in the myocardial tissues of non-diabetic subjects [20-22]. Also, resveratrol (a metabolite of PT) has been extensively studied for its beneficial effects against diabetic myocardial IR through AMPK signaling [23]. A study in AMPK-knockout mice confirmed that AMPK is the central target for metabolic effects of resveratrol [24]. Considering that PT is a parent compound of resveratrol with superior bioavailability and stronger potency [8], high safety profile [11], it is reasonable to hypothesize that PT can also exert a protective effect against diabetic myocardial IR injury via AMPK stimulation.

https://www.karger.com/Article/Pdf/489154
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TimGDixon
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Re: Diabetes and Covid 19

Post by TimGDixon »

Resveratrol is a very cool molecule but as i explained the other day it only has a half life of about 14 minutes - to maintain a relevant level of RSV in the blood you would need it hourly - its cheaper than PTER at about $500 per kilo but thats about all it is. RSV is a great research compound but has very little commercial potential for us - not even worth our time to look at it beyond whats in the lit now.

NanoStilbene on the other hand will remain active in the system of healthy people for 26hrs.

"RSV is not to be dismissed as a viable option for treatment, however, as it was also found that antioxidant treatments using RSV were effective at increasing insulin sensitivity, developing mitochondrial functions, and providing protection against cardiovascular and neurodegenerative diseases. It was also proven to be helpful as the group who was administered a matching dose of both antioxidants did better than all other groups, showing that Resveratrol is still a valuable option in the treatment of type 1 diabetes mellitus."
trader32176
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Re: Diabetes and Covid 19

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This concludes my little side foray into diabetes . As Tim pointed out today :

post by TimGDixon » Thu Jul 23, 2020 3:49 am
Let me add we are not even interested in the patients diabetic state and trying to do something about that - if metformin is already working on that it won't change - dose may need to be slightly increased/adjusted so there is enough active in the system to synergize with QM but we'll find out.

There are several TSOI products in this area of study, but TSOI is not going in this direction as Tim made clear.

The info I shared in this thread was interesting to me , and I hope others have enjoyed reading along .

-Trader
trader32176
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Re: Diabetes and Covid 19

Post by trader32176 »

as time goes by , I need to keep updating this study for those that commented before.
so here goes :

Covid-19 might affect hearing too, a small study shows

8/1/20


https://www.cnn.com/world/live-news/cor ... index.html

Covid-19 might affect hearing too, a small study shows

Some coronavirus survivors have been experiencing hearing problems that lasted until long after they had been released from hospital, a small study has revealed.

Audiologists at the University of Manchester surveyed 121 adults who had been hospitalized with Covid-19 eight weeks after they were released.

When asked about changes to their hearing, 16 people reported their hearing was worse. Eight reported deterioration in hearing and another eight reported tinnitus -- hearing noises that are not caused by an outside source.

The researchers said the results, published in a letter to the International Journal of Audiology, add more anecdotal evidence to our understanding of the long-term effects of coronavirus on health.

Kevin Munro, professor of audiology and the Hearing Health Theme Lead at the Manchester Biomedical Research Centre, said scientists already knew that other viruses such as measles, mumps and meningitis can cause hearing loss and that coronaviruses can damage the nerves that carry information to and from the brain.

“It is possible, in theory, that Covid-19 could cause problems with parts of the auditory system including the middle ear or cochlea," he said.
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TimGDixon
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Re: Diabetes and Covid 19

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not that we're not interested, we are, but we have plenty on our plates now.
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