Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy

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trader32176
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Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy

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Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy

published 15 july , 2021


https://www.nature.com/articles/s41423-021-00732-6


Abstract

Chimeric antigen receptor (CAR)-engineered T-cell (CAR-T) therapy has demonstrated impressive therapeutic efficacy against hematological malignancies, but multiple challenges have hindered its application, particularly for the eradication of solid tumors. Innate killer cells (IKCs), particularly NK cells, NKT cells, and γδ T cells, employ specific antigen-independent innate tumor recognition and cytotoxic mechanisms that simultaneously display high antitumor efficacy and prevent tumor escape caused by antigen loss or modulation. IKCs are associated with a low risk of developing GVHD, thus offering new opportunities for allogeneic “off-the-shelf” cellular therapeutic products. The unique innate features, wide tumor recognition range, and potent antitumor functions of IKCs make them potentially excellent candidates for cancer immunotherapy, particularly serving as platforms for CAR development. In this review, we first provide a brief summary of the challenges hampering CAR-T-cell therapy applications and then discuss the latest CAR-NK-cell research, covering the advantages, applications, and clinical translation of CAR- and NK-cell receptor (NKR)-engineered IKCs. Advances in synthetic biology and the development of novel genetic engineering techniques, such as gene-editing and cellular reprogramming, will enable the further optimization of IKC-based anticancer therapies.
trader32176
Posts: 3265
Joined: Fri Jun 26, 2020 5:22 am

Re: Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy

Post by trader32176 »

Tim, or Tom

Is this article relevant to what TSOI is doing ?

I have read some of the references , but have not subscribed.

-Trader32176
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TimGDixon
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Joined: Fri Jun 26, 2020 4:36 am

Re: Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy

Post by TimGDixon »

In some ways yes - although we are not producing T cells from our cell engineering i suppose we could, instead we are producing immature dendritic cells (DC's) from an induced pluripotent stem cell and then fusing it with an epitope like alpha-gal as well as transfecting the DC with an antigen specific peptide like BORIS or NR2F6. I don't think anyone is actually doing what we're doing but there is a lot of Car-T investigation going on for sure - thats why Franco's at Kite Gilead.
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