Nootropics - for Traumatic Brain Injury/TBI

This forum is to discuss general things concerning TSOI.
curncman
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Is CBD A Nootropic?

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curncman
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Joined: Fri Jun 26, 2020 8:27 am

Hack Your Mitochondria with Nootropics

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Hack Your Mitochondria with Nootropics


curncman
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Joined: Fri Jun 26, 2020 8:27 am

The nootropic and anticholinesterase activities of Clitoria ternatea Linn. root extract: Potential treatment for cogniti

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The nootropic and anticholinesterase activities of Clitoria ternatea Linn. root extract: Potential treatment for cognitive decline

https://www.sciencedirect.com/science/a ... 8620301765

Highlights

Chronic cerebral hypoperfusion (CCH) leads to cognitive decline.


Clitoria ternatea root extract exhibits nootropic effects in CCH rat model.


High dose of Clitoria ternatea root extract inhibits acetylcholinesterase activity.


Clitoria ternatea root extract diminish CCH-induced neuronal damage in CA1 region.


Clitoria ternatea root extract at 200 mg/kg and below was found to be safe in toxicity studies.

Abstract
Background
Clitoria ternatea (CT) is an herbal plant that has been used as a memory booster in folk medicine. CT root extract has been proven to restore chronic cerebral hypoperfusion (CCH)-induced memory deficits in a rat model, but the underlying mechanisms and the toxicity profile following repeated exposure have yet to be explored.

The aim of the study
To investigate the effects of the chronic (28 days) oral administration of CT root extract on CCH-induced cognitive impairment, neuronal damage and cholinergic deficit, and its toxicity profile in the CCH rat model.

Materials and methods
The permanent bilateral occlusion of common carotid arteries (PBOCCA) surgery method was employed to develop a CCH model in male Sprague Dawley (SD) rats. Then, these rats were given oral administration of CT root extract at doses of 100, 200, and 300 mg/kg, respectively for 28 days and subjected to behavioural tests. At the end of the experiment, the brain was harvested for histological analysis and cholinesterase activities. Then, blood samples were collected and organs such as liver, kidney, lung, heart, and spleen were procured for toxicity assessment.

Results
Chronic treatment of CT root extract at doses of 200 and 300 mg/kg, restored memory impairments induced by CCH. CT root extract was also found to diminish CCH-induced neuronal damage in the CA1 region of the hippocampus. High dose (300 mg/kg) of the CT root extract was significantly inhibited the increased acetylcholinesterase (AChE) activity in the frontal cortex and hippocampus of the PBOCCA rats. In toxicity study, repeated doses of CT root extract were found to be safe in PBOCCA rats after 28 days of treatment.

Conclusions
Our findings provided scientific evidence supporting the therapeutic potential of CT root extract in the treatment of vascular dementia (VaD)-related cholinergic abnormalities and subsequent cognitive decline.
curncman
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Re: Nootropics - too profitable $70 USD

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Excelerol Brain Supplement and Memory Support 96 capsules

https://www.walmart.com/ip/Excelerol-Br ... /149077418
curncman
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“Nootropics are the future of functional drinks” – Mintel Insights, October 2020

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Australia-based natural nootropics beverage company, Shine has just nationally launched a new 330ml bottle size in 3 flavours:

Blueberry Lemonade
Peach Passionfruit
Tropical Coconut
The biggest trends in the FMCG industry are all focused on healthy and functional ingredients and consumer benefits. Consumers are getting smarter, they’re becoming more wary of what they put into their bodies; and with no added sugar, artificial colours or flavouring and packed full of natural, age-old functional ingredients (known as ‘nootropics’), Shine energises and awakens the mind and helps consumers think, feel, and do better.

“Nootropics are the future of functional drinks” – Mintel Insights, October 2020

https://www.aacs.org.au/shine-launches- ... ootropics/

The new range was developed in response to the growing popularity of Shine’s original 100ml shot and 400ml sparkling range and is designed to appeal to customers searching for better sources of energy and greater varieties in size and flavours. The new range has a lower RRP which will encourage trial and serve as an entry to the category and brand.

Steve Chapman, CEO & Co-Founder of Shine Drink says that Shine’s growing popularity comes from its ability to satisfy two dominant consumer needs in today’s market.

“The energy drink market has evolved considerably over the last 3-5 years. We’re leading busier lives than ever before and at the same time we’re more health conscious than ever,” says Chapman. “Those are two lifestyle factors that would normally be at odds with one another, but natural nootropics do an incredible job of providing the energy needed to manage a busy lifestyle without compromising on health.”

The recent impacts of COVID-19 have also further contributed to the strong demand for Better Energy products that provide a natural alternative to traditional energy drinks and coffee.

The Shine+ 330ml range is designed for anyone seeking a better energy source; from the health-conscious consumers (those seeking ‘better-for-you’) as well as consumers who are looking to make a change from traditional energy drinks to a better energy boost on the go.


The new range will hit shelves nationally in 7-Eleven, Coles Express, Zambrero, EG Group, selected Coles Supermarkets and Woolworths Metro during the month of October 2020 and retail for $4.95 RRP per bottle. There are more flavours and retailers due to launch before the end of the year.
curncman
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Nootropics - Aurobindo inks pact with New Mountain Capital to sell US-based unit for $550 million

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Aurobindo inks pact with New Mountain Capital to sell US-based unit for $550 million

The drug firm has reached a definitive agreement to sell Natrol, a unit of Aurobindo Pharma USA, Inc, to an affiliate of New Mountain Capital to combine with Jarrow Formulas, Aurobindo Pharma said in a statement.

https://www.moneycontrol.com/news/busin ... 13581.html
curncman
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Protect Your Body From Rheumatoid Arthritis With Pterostilbene

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Protect Your Body From Rheumatoid Arthritis With Pterostilbene


curncman
Posts: 905
Joined: Fri Jun 26, 2020 8:27 am

Nootropics - Top 7 Nootropic Adaptogens to Conquer Anxiety and Stress

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Top 7 Nootropic Adaptogens to Conquer Anxiety and Stress


curncman
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Joined: Fri Jun 26, 2020 8:27 am

Nootropics -VeloVita is the best c7ognitive enhancer supplements online - now learn why!

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VeloVita is the best cognitive enhancer supplements online - now learn why!

curncman
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Joined: Fri Jun 26, 2020 8:27 am

Re: Nootropics - What are the benefits of Coluracetam powder

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What are the benefits of Coluracetam powder




Coluracetam is one of the newer and lesser known racetam nootropics, but it's a favorite for many. Studies suggest that it can enhance cognition and memory, and users report that it also improves concentration, focus, and vision.

Coluracetam is a new and unique member of the racetam class of synthetic nootropics. Originally developed as a potential treatment for Alzheimer’s disease and later considered as a treatment for depression and anxiety, coluracetam has become a popular nootropic known for improving mood, increasing motivation, and enhancing vision.

Coluracetam was first synthesized in 2005 by Japan’s Mitsubishi Tanabe Pharma Corporation as an Alzheimer’s disease treatment. After disappointing clinical trials, coluracetam was licensed to US biotechnology firm BrainCells Inc., which started testing the compound as a treatment for depression and anxiety. Though initial test results were positive and suggested that further study of coluracetam would be worthwhile,‍[1] development was discontinued, and BrainCells, Inc. closed in 2014.‍[2] Coluracetam has been available for licensing since 2012.‍[3]

Coluracetam acts primarily as a choline uptake enhancer that selectively affects memory function.‍[4] It specifically enhances high-affinity choline uptake, increasing levels of the neurotransmitter acetylcholine by providing more of the choline from which it is made. Since acetylcholine is the neurotransmitter most closely associated with memory and cognition, it is believed that this function is the primary source of coluracetam’s nootropic capabilities.‍[5]

Coluracetam is particularly potent and requires a much smaller dose than other racetam class nootropics. It’s fast-acting, reaching high levels in plasma within 30 minutes of ingestion, but within three hours, levels are in decline.‍[6]

Coluracetam is unregulated in the US and is sold as a dietary supplement, but its legal status varies from country to country. It cannot be legally sold in Canada and the UK except by prescription, but it can be legally imported and possessed.

Benefits and Effects of Coluracetam
There have been few documented human studies on coluracetam, so most of the information available is based on animal testing. However, research results and self-reports from users suggest that coluracetam may provide a variety of both cognitive and physical/sensory benefits.

Memory and Learning
Coluracetam has been shown to improve cognitive function and memory in rats, and in theory, similar results may translate to humans.

In a 2010 animal study, coluracetam improved artificially-induced memory deficits without producing any significant side effects. The positive results were still apparent three days after the last dose, even though coluracetam’s serum concentration was negligible.‍[7]

Some users say coluracetam dramatically improves short-term memory and free recall,‍[8] increases memorization and recall abilities and enhances reading comprehension,‍[9] and increases thought and learning speed and information retention.‍[10]

Depression and Anxiety
The Phase 2a clinical trial of coluracetam suggested that it may be effective for treatment-resistant patients with depression and anxiety.

The six-week placebo-controlled study, which was one of the few coluracetam tests involving humans, determined that a dosage of 240 mg (split into three daily doses of 80 mg) was useful in treating major depressive disorder (MDD) with comorbid generalized anxiety disorder (GAD).

At the end of the test period, the overall treatment group and the placebo group scored similarly on scales for depression and anxiety. Still, there was a measurable improvement in the subset of treatment group participants who had both MDD and GAD, and who had previously failed an average of two antidepressants.‍[11]

User reports on coluracetam’s effect on anxiety and depression vary considerably, with some saying it alleviates both‍[12] and is a potent and reliable mood booster,‍[13] while others say it can actually trigger depression and anxiety.‍[14]

Eyesight
Coluracetam’s effect on vision is frequently reported by users, who say it enhances color vision, shape recognition, and optical vividness.‍[15]‍[16] Some users describe the effect as “HD vision”‍[17] while others say it makes lights brighter and intensifies contrast.‍[18]

Though enhanced vision is one of coluracetam’s most commonly reported benefits, there is no conclusive scientific evidence to explain or confirm this effect.

How It Works
Like most racetam compounds, coluracetam works mainly by increasing levels of the neurotransmitter acetylcholine, which is strongly associated with learning, memory, and cognition.

However, the way that coluracetam modulates acetylcholine levels is unique. Typically, racetams trigger acetylcholine production by stimulating the appropriate receptors, but coluracetam does so by enhancing high-affinity choline uptake, or HACU. The HACU system determines the rate at which choline is drawn into neurons for conversion into acetylcholine.

By increasing the rate at which choline is drawn into nerve cells, coluracetam promotes acetylcholine production and causes brain levels of this crucial neurotransmitter to rise.‍[19] It has also been shown to create an increase in the high-affinity choline transporter molecule CHT1, which leads to the rapid availability of choline for uptake.

Together these actions lead to higher levels of acetylcholine, which are associated with enhanced cognition and memory.

Dosage
Most of the research on coluracetam was done on animals rather than humans, so there are no universally accepted dosing guidelines. The active dosage range is generally described as 5–20 mg, though users report a wide range of doses taken both orally and sublingually.‍[20]

Many users note that tolerance may develop quickly,‍[21] but there is no research data on that aspect of coluracetam.

As is true with all nootropics, it’s generally best to begin dosing at the lower end of the range to determine your reaction to the substance and increase as necessary.

Side Effects
None of the animal or human studies on coluracetam documented any side effects.

The lack of adverse side effects was considered one of the most notable aspects of the animal study in which coluracetam was shown to offset artificially induced memory deficits in rats.‍[22]

The most commonly reported side effect associated with racetam class nootropics is headache, which can often be eliminated by taking additional choline.

Coluracetam users have also reported intermittent nausea and daytime sleepiness as negative side effects, both of which were lessened by reducing the dosage.‍[23]

Stacking
Like most racetams, coluracetam stacks well with a choline source, such as alpha GPC, for added memory and cognitive benefits.

The recommended doses for supplemental choline is 300–600 mg daily if you’re stacking with alpha GPC and 250–750 mg daily if you’re using CDP choline.
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