Nootropics - for Traumatic Brain Injury/TBI

This forum is to discuss general things concerning TSOI.
curncman
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Nootropics - for Traumatic Brain Injury/TBI

Post by curncman »

Nootropics - for Traumatic Brain Injury/TBI






1:25 / 12:26


Best Nootropics for Studying

curncman
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The BEST Nootropics To Take (AVOID THESE!!) Biohacking Expert Dr. Molly Maloof | MIND PUMP

Post by curncman »

The BEST Nootropics To Take (AVOID THESE!!) Biohacking Expert Dr. Molly Maloof | MIND PUMP



Dr. Molly Maloof - Glucose Monitoring, Mitochondrial Stress, & Mental Health





Conversation w/ Dr. Molly Maloof, MD

curncman
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Re: Nootropics - for Traumatic Brain Injury/TBI

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curncman
Posts: 432
Joined: Fri Jun 26, 2020 8:27 am

Re: Nootropics - for Traumatic Brain Injury/TBI

Post by curncman »

NEUROPLASTICITY, PSYCHEDELICS, AND BOOSTING IMMUNITY - Dr. Molly Maloof, M.D

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TimGDixon
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Re: Nootropics - for Traumatic Brain Injury/TBI

Post by TimGDixon »

Nootropics is a fascinating field - expect to hear more about this from us in the future.
curncman
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Re: Nootropics - for Traumatic Brain Injury/TBI

Post by curncman »

Great to hear TIm! you are all over and seems like you have touched every possible natural therapy clinical solutions that are currently at the forefront of treatment of options available for patients with no option with FDA approved allopathy medicines. This Nootropics market is getting HUGE attention from elite society to beat the stressful daily high life as Doctor, Businessmen, Scientists, Astronauts, Soldiers , Law makers etc, if you have something from TSOI LAB it will be smashing HIT and will open immediate revenue making streams and partnerships from healthcare, BIG PHAROAH and Wellness and insurance companies.

As always I am glad that already I have small position in TSOI as these PPS levels and I wish I had tons of them to build a fortune for my kids. :lol: :lol: :lol: :lol: :lol: :lol: :lol: :lol:
curncman
Posts: 432
Joined: Fri Jun 26, 2020 8:27 am

Nootropics -Brain Plasticity

Post by curncman »

Brain Plasticity and Nootropics



Global Nootropics Market Is Set To Reach USD 5,959 Million By 2024

iCrowd Newswire - Oct 7, 2020

Zion Market Research has published a new report titled “Nootropics Market By Application (Memory Enhancement, Mood and Depression, Attention and Focus, Longevity and Anti-Aging, Sleep, Recovery, and Dream Enhancement, and Anxiety): Global Industry Perspective, Comprehensive Analysis, and Forecast, 2017—2024”. According to the report, the global nootropics market was valued at around USD 1,324 million in 2017 and is expected to reach approximately USD 5,959 million by 2024, at a CAGR of around 15.7% between 2018 and 2024.

Nootropics are also known as cognitive enhancers or smart drugs. These include supplements, drugs, and other related substances that can advance cognitive function, mainly executive functions, motivation, creativity, memory, or attention in healthy individuals. Nootropics can be synthetic or natural substances that are preferred widely to enhance an individual’s mental performance. Caffeine, L-Theanine, Creatine, Bacopa Monnieri, and Rhodiola Rosea are some of the popularly used nootropics.
curncman
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Nootropics -Key Protein Identified as the Link Between Chronic Stress and Depression

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Key Protein Identified as the Link Between Chronic Stress and Depression

https://www.prohealthlongevity.com/blog ... depression

A protein in the brain, p11, is responsible for regulating the feel-good hormone serotonin and the stress hormone cortisol in mice.

People with depression have lower levels of p11 and mice with reduced p11 levels show depression- and anxiety-like behavior.

Mice with p11 deficiency react more strongly to stress, with a higher heart rate and more signs of anxiety.

The discovery of this protein may lead to the development of new drugs for depression or anxiety.

This article was posted on Karolinska Institutet News:

Researchers at Karolinska Institutet in Sweden have identified a protein in the brain that is important both for the function of the mood-regulating substance serotonin and for the release of stress hormones, at least in mice. The findings, which are published in the journal Molecular Psychiatry, may have implications for the development of new drugs for depression and anxiety.

After experiencing trauma or severe stress, some people develop an abnormal stress response or chronic stress. This increases the risk of developing other diseases such as depression and anxiety, but it remains unknown what mechanisms are behind it or how the stress response is regulated.

The research group at Karolinska Institutet has previously shown that a protein called p11 plays an important role in the function of serotonin, a neurotransmitter in the brain that regulates mood. Depressed patients and suicide victims have lower levels of the p11 protein in their brain, and laboratory mice with reduced p11 levels show depression- and anxiety-like behaviour. The p11 levels in mice can also be raised by some antidepressants.

The new study shows that p11 affects the initial release of the stress hormone cortisol in mice by modulating the activity of specific neurons in the brain area hypothalamus. Through a completely different signalling pathway originating in the brainstem, p11 also affects the release of two other stress hormones, adrenaline and noradrenaline. In addition, the tests showed that mice with p11 deficiency react more strongly to stress, with a higher heart rate and more signs of anxiety, compared to mice with normal p11 levels.

"We know that an abnormal stress response can precipitate or worsen a depression and cause anxiety disorder and cardiovascular disease," says first author Vasco Sousa, researcher at the Department of Clinical Neuroscience, Karolinska Institutet. "Therefore, it is important to find out whether the link between p11 deficiency and stress response that we see in mice can also be seen in patients."

The researchers believe that the findings may have implications for the development of new, more effective drugs. There is a great need for new treatments because current antidepressants are not effective enough in many patients.

"One promising approach involves administration of agents that enhance localised p11 expression, and several experiments are already being conducted in animal models of depression," says Per Svenningsson, professor at the Department of Clinical Neuroscience, Karolinska Institutet, who led the study. "Another interesting approach which needs further investigation involves developing drugs that block the initiation of the stress hormone response in the brain."

This study was published in Molecular Psychiatry in October 2020.
curncman
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Nootropics -Identification of Molecular Network Associated with Neuroprotective Effects of Yashtimadhu (Glycyrrhiza glab

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Identification of Molecular Network Associated with Neuroprotective Effects of Yashtimadhu (Glycyrrhiza glabra L.) by Quantitative Proteomics of Rotenone-Induced Parkinson’s Disease Model

https://www.x-mol.com/paper/1313556413736521728

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, whose treatment with modern therapeutics leads to a plethora of side effects with prolonged usage. Therefore, the management of PD with complementary and alternative medicine is often pursued. In the Ayurveda system of alternative medicine, Yashtimadhu choorna, a Medhya Rasayana (nootropic), prepared from the dried roots of Glycyrrhiza glabra L. (licorice), is prescribed for the management of PD with a favorable outcome. We pursued to understand the neuroprotective effects of Yashtimadhu choorna against a rotenone-induced cellular model of PD using differentiated IMR-32 cells. Cotreatment with Yashtimadhu choorna extract rescued rotenone-induced apoptosis and hyperphosphorylation of ERK-1/2. Quantitative proteomic analysis of six peptide fractions from independent biological replicates acquired 1,561,169 mass spectra, which when searched resulted in 565,008 peptide-spectrum matches mapping to 30,554 unique peptides that belonged to 4864 human proteins. Proteins commonly identified in biological replicates and >4 PSMs were considered for further analysis, leading to a refined set of 3720 proteins. Rotenone treatment differentially altered 144 proteins (fold ≥1.25 or ≤0.8), involved in mitochondrial, endoplasmic reticulum, and autophagy functions. Cotreatment with Yashtimadhu choorna extract rescued 84 proteins from the effect of rotenone and an additional regulation of 4 proteins. Network analysis highlighted the interaction of proteins and pathways regulated by them, which can be targeted for neuroprotection. Validation of proteomics data highlighted that Yashtimadhu confers neuroprotection by preventing mitochondrial oxidative stress and apoptosis. This discovery will pave the way for understanding the molecular action of Ayurveda drugs and developing novel therapeutics for PD.
curncman
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Re: Nootropics - for Traumatic Brain Injury/TBI

Post by curncman »

More than 2000 years ago, the Roman poet Virgil wrote, “Time robs us of all, even of memory.”

Humans have long recognized the insidious toll that aging takes on the body – including the brain. But it is only very recently in our history as a species that we have been able to conceive of plausible ways to halt or even reverse it. As we gradually unveil the fundamental mechanisms of biological aging, we are starting to develop interventions that directly combat the diseases emanating from this process.
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