Pandemic News Links / Current News Updates

curncman
Posts: 1007
Joined: Fri Jun 26, 2020 8:27 am

What is the South Indian N440K COVID-19 variant and why is it 15 times more lethal

Post by curncman »

What is the South Indian N440K COVID-19 variant and why is it 15 times more lethal

What is the South Indian N440K COVID-19 variant and why is it 15 times more lethal
The N440K variant of coronavirus is majorly witnessed in Telangana, Andhra Pradesh, Karnataka, parts of Maharashtra and Chhattisgarh.

Image

Even as the Indian variant of the SARS-CoV-2, known as B.1617 is wreaking havoc, researchers from Hyderabad have found a new mutant in parts of southern India and more specifically in Andhra Pradesh that is 15 times more lethal than the previous strains. The N440K variant of coronavirus is majorly being seen in Telangana, Andhra Pradesh, Karnataka, parts of Maharashtra and Chhattisgarh.

Scientists at the Centre for Cellular and Molecular Biology (CCMB) discovered the new coronavirus variant N440K. This variant was first discovered in Kurnool at Andhra Pradesh. It is said to be at least 10 times more infectious.

District COVID Special Officer and Principal of Andhra Medical College PV Sudhakar confirmed the enhanced power of the virus and was quoted by The Hindu as saying, “We have observed that the new variant has shorter incubation period and the progress of the disease is much rapid. In the earlier cases, a patient affected with the virus would take at least a week to reach the hypoxia or dyspnea stage. But in the present context, patients are reaching the serious condition-stage within three or four days. And that is why there is heavy pressure on beds with oxygen or ICU beds.”

ALSO READ
Covaxin neutralises double mutant strain, effective against multiple variants of SARS-CoV-2: ICMR
According to reports, the new variant has a shorter incubation period and the progress of the disease is much rapid. Hence, a shorter exposure is enough to acquire the virus. This enables an infected person to infect more four to five persons within a shorter span of time.

"The timing of the increase in B.1.617 coincides well with the second waves seen in the respective states," finds Divya Tej Sowpati of CCMB as quoted by India Today.

ALSO READ
COVID-19 triple mutation strain detected in 4 Indian states - all you need to know
"In Kerala, though not much data is available on GISAID, we can see from genescov2.genomes.in that B.1.1.7 is increasing at present, whereas N440K is present in less than 20 per cent of the genomes," he further added.

While N440K was indeed a mutation of concern in South India, new data shows that it is slowly being replaced by new variants of concerns (VoCs) such as B.1.617 (dubbed a double-mutant variant) and B.1.1.7 (variant identified in the UK). There is no need for people to panic about the N440K variant of Covid-19 as this strain shall fade away in the coming weeks, said experts.

New Symptoms

According to Dr Shuchin Bajaj, Founder and Director, Ujala Cygnus Group of Hospitals, "We are seeing new Covid strain, and some newer symptoms are found in patients like fever, pain in muscles, dry and persistent cough, and loss of smell and taste. In addition to conjunctivitis, sore throat, headache, rashes, upset stomach, and discolouration of fingers and toes."

According to reports, the new variant has a shorter incubation period and the progress of the disease is much rapid. Hence, a shorter exposure is enough to acquire the virus. This enables an infected person to infect more four to five persons within a shorter span of time.

"The timing of the increase in B.1.617 coincides well with the second waves seen in the respective states," finds Divya Tej Sowpati of CCMB as quoted by India Today.

"In Kerala, though not much data is available on GISAID, we can see from genescov2.genomes.in that B.1.1.7 is increasing at present, whereas N440K is present in less than 20 per cent of the genomes," he further added.

While N440K was indeed a mutation of concern in South India, new data shows that it is slowly being replaced by new variants of concerns (VoCs) such as B.1.617 (dubbed a double-mutant variant) and B.1.1.7 (variant identified in the UK). There is no need for people to panic about the N440K variant of Covid-19 as this strain shall fade away in the coming weeks, said experts.

New Symptoms

According to Dr Shuchin Bajaj, Founder and Director, Ujala Cygnus Group of Hospitals, "We are seeing new Covid strain, and some newer symptoms are found in patients like fever, pain in muscles, dry and persistent cough, and loss of smell and taste. In addition to conjunctivitis, sore throat, headache, rashes, upset stomach, and discolouration of fingers and toes."
curncman
Posts: 1007
Joined: Fri Jun 26, 2020 8:27 am

COVID-19 Update with Dr. Auwaerter of Johns Hopkins: Vaccines and Variants (May 2021)

Post by curncman »

COVID-19 Update with Dr. Auwaerter of Johns Hopkins: Vaccines and Variants (May 2021)

trader32176
Posts: 2688
Joined: Fri Jun 26, 2020 5:22 am

Re: Pandemic News Links / Current News Updates

Post by trader32176 »

Vaccines and variants

trader32176
Posts: 2688
Joined: Fri Jun 26, 2020 5:22 am

Re: Pandemic News Links / Current News Updates

Post by trader32176 »

Vaccines vs. Variants

trader32176
Posts: 2688
Joined: Fri Jun 26, 2020 5:22 am

Re: Pandemic News Links / Current News Updates

Post by trader32176 »

Vaccines appear to protect against some Covid variants, but not others: Professor

curncman
Posts: 1007
Joined: Fri Jun 26, 2020 8:27 am

How does our immune system react to vaccination?

Post by curncman »

How does our immune system react to vaccination?


curncman
Posts: 1007
Joined: Fri Jun 26, 2020 8:27 am

The Spike: How Your Brain Uses Electrical Impulses to Communicate - with Mark Humphries

Post by curncman »

The Spike: How Your Brain Uses Electrical Impulses to Communicate - with Mark Humphries


curncman
Posts: 1007
Joined: Fri Jun 26, 2020 8:27 am

A Phase III Trial Evaluating Iomab-B Prior to HCT in Relapsed/Refractory AML

Post by curncman »

A Phase III Trial Evaluating Iomab-B Prior to HCT in Relapsed/Refractory AML

curncman
Posts: 1007
Joined: Fri Jun 26, 2020 8:27 am

A potentially fatal fungal infection is cropping up among India’s Covid patients.

Post by curncman »

A potentially fatal fungal infection is cropping up among India’s Covid patients.

https://www.nytimes.com/2021/05/09/worl ... &smtyp=cur

Image

NEW DELHI — Doctors in India are concerned about an increasing number of potentially fatal fungal infections affecting either people who have Covid-19 or those who have recently recovered from the disease.

The condition, known as mucormycosis, has a high mortality rate and was present in India before the pandemic. It is caused by a mold that thrives in wet environments and can attack through the respiratory tract, potentially eroding facial structures and harming the brain.

The condition is relatively rare, but doctors and medical experts say it seems to be infecting some Covid patients whose weakened immune systems and underlying conditions, particularly diabetes, leave them vulnerable.

Some experts attribute the fungal infections to an increased use of steroids to treat hospitalized patients. Another factor could be that, with hospitals overwhelmed in this second wave of the pandemic, many families are self-medicating and applying oxygen therapy at home without the proper hygiene, experts say.

In the western state of Maharashtra, which includes the commercial hub of Mumbai and has been badly devastated by the pandemic, local news media reported that around 200 patients who had recovered from Covid were being treated for mucormycosis and that eight had died.

In Gujarat, a western state north of Maharashtra, the state government ordered the allocation of separate wards in hospitals for the treatment of the infection, and said it had put purchase orders for 5,000 doses of amphotericin b, a medicine used to treat it. Infections have also been reported in hospitals in the country’s capital, New Delhi.

Health experts are keeping close tabs on the situation. “We have heard that in some areas, people who are Covid-infected or recovered suffer from mucormycosis, but there is not big outbreak of it,” Dr. V.K. Paul, who heads India’s Covid task force, said last week. “We are watching and monitoring.”

“It is a fungus that has a strong relation to diabetes,” he added. “If the person is not diabetic, it is very uncommon that the person would have mucormycosis.

Many less populous countries have higher percentages of diabetes, but only one — China, with a population even larger than India’s 1.38 billion — has a higher raw number of diabetics. In India, more than 10 percent of the adult population has the condition, or 77 million people. China has more than 116 million adult diabetics, or 9 percent, according to the 2019 International Diabetes Foundation Atlas.
Dr. K. Srinath Reddy, who leads the Public Health Foundation of India, said a large number of the recent reported mucormycosis cases are of hospitalized coronavirus patients who have been discharged after their recovery.

“You are using steroids to reduce the hyperimmune response, which is there in Covid,” Dr. Reddy said. “But you are reducing the resistance to other infections.”
curncman
Posts: 1007
Joined: Fri Jun 26, 2020 8:27 am

New antibody drug helps patients breathe; virus may insert genetic fragments into genetic code

Post by curncman »

New antibody drug helps patients breathe; virus may insert genetic fragments into genetic code

https://us.yahoo.com/news/antibody-drug ... 25524.html

Image
Post Reply